Studies indicate that cannabis use may protect against Osteoporosis otherwise known as brittle bone disease. Recently, the main components of the endocannabinoid system, namely the CB1 and CB2 receptors, along with the two main endocannabinoids; Anandamide and 2-AG, have been found in the human skeleton and they are reported to be involved in the regulation of bone metabolism.
Cannabinoid Receptors as Target for Treatment of Osteoporosis
“The central nervous system plays an important role in regulating bone metabolism in health and in disease with a number of neurotransmitters been reported to influence bone cell activity through a central relay. In keeping with this, recent studies demonstrated that endocannabinoids and their receptors are involved in the pathogenesis of osteoporosis”
“There is a steadily growing body of evidence suggesting that the skeletal endocannabinoid system plays an important role in the regulation of bone mass in health and in disease. Cell and tissue based studies showed that bone cells express cannabinoid receptors and the machinery for the synthesis and breakdown of endocannabinoids, thereby indicating that endocannabinoids influence bone remodelling acting on CB1 and CB2 receptors expressed on bone cells”
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