Incontinence and Overactive Bladder
Over activity and incontinence are common in the following conditions: old age, Diabetes, Brain or spinal injury, Parkinson’s, Stress, Stroke, MS and others.
According to the International Continence Society, OAB (overactive bladder) was defined as:
“urgency, with or without urge incontinence, and usually with frequency and nocturia”
Research Findings on Overactive Bladder
“Cannabinoids seem to be a promising area for future drug development research on OAB due to their involvement in controlling LUT function in animals and humans especially, in patients with MS”
Download the .pdf: Here
Inflammation (General) Also see: Arthritis
Inflammation is a key factor in many illnesses and diseases, e.g. arthritis is inflammation of the joints, heart disease involves inflammation of the arteries. The conventional treatment to combat inflammation is to prescribe anti-inflammatory drugs. Cannabinoids (and some terpenes) have anti-inflammatory properties and they can be an effective treatment as they treat the cause of the inflammation and not just relieve the symptoms. As with most illnesses, diet can play a key role.
Some foods that promote inflammation:
– Oils, such as corn and soybean
– Pasteurized dairy
– Refined carbohydrates
– Conventional meat
– Trans fats
Adopting a healthy diet is an important factor in treating any illness or disease, food sources that are high in antioxidants can help to reduce the damage caused by inflammation. Often referred to as the Mediterranean diet it contains many anti-inflammatory foods.
The website eatingwell reports:
“Perhaps the world’s healthiest diet, the Mediterranean Diet is abundant in fruits, vegetables, whole grains, legumes and olive oil. It features fish and poultry—lean sources of protein—over red meat, which contains more saturated fat. Red wine is consumed regularly but in moderate amounts.
Research suggests that the benefits of following a Mediterranean-style eating pattern may be many: improved weight loss, better control of blood glucose (sugar) levels and reduced risk of depression, to name a few. Eating like a Mediterranean has also been associated with reduced levels of inflammation, a risk factor for heart attack, stroke and Alzheimer’s disease and has been shown to lower cholesterol, triglycerides and reduce symptoms of rheumatoid arthritis. The diet has also been linked to reduced risk of Alzheimer’s disease, cancer, cardiovascular disease and diabetes”
A bonus of eating a healthy diet is weight loss and reducing the amount of excess fatty acids circulating in the blood assists in promoting an inflammatory immune response.
Dr Nicholas Perricone (a leading proponents of the anti-inflammatory diet) says:
“All foods fit into three categories: pro-inflammatory, neutral or anti-inflammatory”
He goes on to add that some foods can be called anti-inflammatory “super-foods”
- Acai fruit
- Allium vegetables (chives, garlic, leeks, onions, scallions and shallots)
- Beans and lentils
- Green foods
- Hot peppers
- Nuts and seeds
A minimum of 4 to 5 servings per day of beets, carrots, cruciferous vegetables (broccoli, cabbage, cauliflower and kale) dark, leafy greens (collard greens, kale, spinach), onions, peas, salad greens, sea vegetables and squashes.
Fruits, 3 to 4 servings per day of apples, blackberries, blueberries, cherries, nectarines, oranges, pears, pink grapefruit, plums, pomegranates, red grapefruit or strawberries.
Drink purified water, sparkling water or unsweetened tea throughout the day.
Beans and Legumes
1 to 2 servings per day of Ansazi beans, adzuki beans, black beans, black-eyed peas, chickpeas or lentils.
5 to 7 servings per day of avocadoes, expeller-pressed organic canola oil, extra virgin olive oil, flaxseed, hazelnut oil, hemp seeds, high-oleic safflower or sunflower oils, sesame oil or walnut oil.
Healthy Herbs and Spices
Unlimited amounts of basil, chili peppers, cinnamon, curry powder, garlic, ginger, rosemary and thyme.
1 to 2 servings per week of eggs, grass-fed meats, natural cheeses, organic poultry, yogurt.
Cannabinoids as novel anti-inflammatory drugs
“Cannabinoids are potent anti-inflammatory agents and they exert their effects through induction of apoptosis, inhibition of cell proliferation, suppression of cytokine production and induction of T-regulatory cells”
Download the .pdf: Here
Cannabinoids, Endocannabinoids, and Related Amalog’s in Inflammation
“Possibly the very earliest literature reference on Cannabis describes its use as an anti-inflammatory agent. The Chinese emperor Shen-nung (ca. 2000 B.C.), in a work called Pen-ts’ao Ching, noted many of the effects of Cannabis in humans. Among other properties, it was claimed that cannabis “undoes rheumatism”, suggesting possible anti-inflammatory effects”
Download the .pdf: Here
Understanding auto-inflammatory diseases
“When your body is attacked—perhaps by a virus or other germs—your immune system defends you. It “sees” and kills the germs that might hurt you. But when the system doesn’t work right, this process can cause harm. Immune cells can mistake your body’s own cells as invaders and attack them. This “friendly fire” can affect almost any part of the body. It can sometimes affect many parts of the body at once. This is called “autoimmunity” (meaning “self-immunity)”
Download the .pdf: Here
Cannabinoids and neuro-inflammation
“Cells involved in neuro-inflammation express functional cannabinoid receptors and produce and degrade endocannabinoids, suggesting that the endocannabinoid signalling system has a regulatory function in the inflammatory response. Specifically, during neuro-inflammation, there is an upregulation of components involved in the cannabinoid signalling system. This suggests that the cannabinoid signalling system participates in the complex development of this disease, which includes a tight orchestration of the various immune cells involved”
Download the .pdf: Here
Insomnia is a sleep disorder which affects around a third of adults, sufferers generally report one (or more) of the following symptoms:
- Difficulty in falling asleep
- Interrupted sleep, waking up often during the night
- Awaking too early
- Feeling fatigued & tired upon waking and throughout the day
The age group most effected by insomnia are the over sixties, around 40% of pensioners suffer from some form of sleep disorder. The in-depth report on the sleep aid industry “Global Sleep Aids Market” states:
“Globally, the sleep aids market is witnessing significant growth due to growing aging population, increasing demand for sleeping pills due to stressful modern lifestyle, and rising initiatives by various health organizations to increase awareness about sleep disorders “
Cannabinol (CBN) by Jeff Ditchfield
Cannabinol, was the first cannabinoid (phytocannabinoid) to be isolated, from an extract of cannabis, at the end of the 19th century.
Of the 80 cannabinoids produced by the cannabis plant tetrahydrocannabinol (THC) is the most studied, however as much of the research conducted since the 1970’s has been US Government sponsored as part of their “war on drugs” research has tended to focus on the psychoactive effects of THC.
In recent years some progressive Governments around the World have changed their attitudes to cannabis and research is now being conducted into all cannabinoids and their medical benefits.
What Is Cannabinol?
The cannabis plant produces cannabinoids within small glandular structures called trichomes which are predominantly found in flowering female plants, the trichomes are often referred to as “resin glands”.
Whereas all plant derived cannabinoids originate from the precursor cannabigerolic acid (CBGA), CBN is not a cannabinoid produced by the cannabis plant, CBN is actually created by the oxidisation of THC.
The respected US “Steep Hill Laboratory” report:
“Of all the cannabinoids, CBN appears to be the most sedative. Not only is it sedative, it takes very little to do the job. The consumption of 2.5mg to 5mg of CBN has the same level of sedation as a mild pharmaceutical sedative, with a relaxed body sensation similar to 5mg to 10mg of diazepam. CBN is synergistic with both CBD and D9THC for inducement of sleeping, and when mixed in the correct ratios, CBN becomes an effective sleep aid of 5-6 hours’ duration. Read more: Here
As we do more research focused on CBN, we will no doubt discover more fascinating properties of this often misunderstood cannabinoid. In the meantime, CBN appears to be a beneficial alternative to THC for treatment, and patients that require low (or no) adverse psychoactive effects.”
The highest CBN content Steep Hill Lab have ever recorded is 5.5% and that was far from a pure compound as the sample concerned recorded a THC level of 70%
The extraction processes developed by Bud Buddies in Spain produces much higher levels of CBN than those recorded by Steep Hill Lab’s (our highest so far is 28%), however it is the lack of other cannabinoids that makes this particular extract legal in some countries and jurisdictions.
CBN Preparations & Products
In addition to CBN in capsule form (5mg per capsule) Bud Buddies are conducting research into CBN and CBD combinations, e.g. our strains with a 2:1 CBD:THC cannabinoid ratio can be converted into 2:1 CBD:CBN profile, combining CBD with CBN should enhance the sedative effects of the product and capsules containing these compounds could be another product line.
“Of all the cannabinoids, CBN appears to be the most sedative. Not only is it sedative, it takes very little to do the job. The consumption of 2.5mg to 5mg of CBN has the same level of sedation as a mild pharmaceutical sedative.